What are the ways to keep calcium from triggering release, and what does each one act on? · Lobeworks/17

Four, by where they act.

What are the ways to keep calcium from triggering release, and what does each one act on?

Four, by where they act. At the pore, toxins block by channel type (ω-conotoxin GVIA the N-type, ω-agatoxin IVA the P/Q-type), cadmium blocks nearly all, and magnesium competes with calcium outside. In the membrane, Lambert-Eaton antibodies remove P/Q channels and gabapentin binding the α2δ subunit reduces how many arrive. In the gating, GABA-B and CB1 receptors make the channels harder to open. After entry, the fast chelator BAPTA catches calcium before it reaches the sensor, where the slow EGTA often cannot. Each one lowers the release probability, and steeply, since release grows with about the fourth power of calcium.