How do gap junctions between interneurons help the cortex oscillate? · Grey Matter

Fast-spiking interneurons of the same type are linked by gap junctions made of connexin 36, so when some of them depolarise, current leaks into their neighbours and pulls them toward firing at the same moment.

How do gap junctions between interneurons help the cortex oscillate?

Fast-spiking interneurons of the same type are linked by gap junctions made of connexin 36, so when some of them depolarise, current leaks into their neighbours and pulls them toward firing at the same moment. Synchronised interneurons deliver their inhibition to many pyramidal cells together, opening and closing a common window for firing, which is the core of gamma rhythms. The coupling passes slow voltage changes better than brief spikes, so it aligns the cells' rhythm more than it transmits individual spikes. Mice lacking connexin 36 still oscillate, but with weaker gamma, which shows the junctions help without being the only mechanism.