How does a dopamine neuron limit its own release? · Grey Matter

Dopamine terminals and cell bodies carry D2 receptors that respond to the dopamine they have just released.

How does a dopamine neuron limit its own release?

Dopamine terminals and cell bodies carry D2 receptors that respond to the dopamine they have just released. Through inhibitory G proteins these autoreceptors reduce calcium entry and release at the terminal, slow the cell's firing at the soma, and turn down the synthesis of new dopamine. The loop keeps release in range: blocking D2 autoreceptors, as some antipsychotics do in part, transiently increases dopamine release and synthesis. Together with reuptake by the dopamine transporter, this feedback shapes how long a burst of dopamine lasts.