Can a spreading depression stop a seizure that set it off? · Grey Matter

In several animal models it can: a seizure raises extracellular potassium and glutamate until the tissue tips into spreading depression, and the depression immediately silences the seizure where it passes and keeps it from generalising.

Can a spreading depression stop a seizure that set it off?

In several animal models it can: a seizure raises extracellular potassium and glutamate until the tissue tips into spreading depression, and the depression immediately silences the seizure where it passes and keeps it from generalising. The two outcomes of the excitability map are therefore linked as well as opposed, since the collapse of the gradients removes the charge that the seizure needs. Whether the same sequence ends seizures in people, and whether it contributes to the confusion and weakness after some seizures, is still being studied.